Dysgenesis of the corpus callosum and anterior commissure have been identified in patients harboring mutations in the TUBB3 gene, which cause two distinct clinical entities, named Cortical Dysplasia, Complex, with other Brain Malformations 1 (CDCBM1) and Congenital Fibrosis of the Extraocular Muscles 3 (CFEOM3) [98,99]. Here, TUBB3 is linked to cerebral malformation.