Tanshinone I, one of the major compounds of Salvia miltirrhiza, exerts cytotoxicity associated with p62 accumulation and conversion of the LC3-I soluble form to the LC3-II autophagic vesicle-associated form in malignant pleural mesothelioma cells, and this phenomenon was significantly inhibited by the JNK inhibitor SP600125, indicating that JNK activation is critical for tanshinone I-induced p62-dependent autophagy [52]. This evidence concerns the gene MAPK8 and malignant pleural mesothelioma.