MAPK8 and chronic myelogenous leukemia, BCR-ABL1 positive: Resveratrol, a natural polyphenol found in grapes, protects chronic myelogenous leukemia (CML) cells from stress-induced apoptosis through its antioxidant effects, whereas it promotes autophagic cell death in CML cells via JNK-mediated p62 upregulation [49].