Curcumin, a polyphenol isolated from the rhizome of Curcuma longa, is known to exploit anticancer effects through downregulation of the PI3K-Akt-mTOR pathway in head and neck cancer cells [39], and downregulation of the Wnt/β-catenin pathway by Akt inhibition is associated with antimony (Sb)-induced neurotoxicity [40]. The gene discussed is AKT1; the disease is head and neck cancer.