CXCL8 and colorectal carcinoma: As can be seen, the angiogenesis-promoting effects of the CM collected from the GATA6-overexpressing clones were dramatically suppressed by the addition of either ki8751 (Figure 3D) or the IL-8-neutralizing antibody (Figure 3E), suggesting that VEGF-A and IL-8 are the main proangiogenic factors present in the GATA6-overexpressing human CRC clones.