Several studies indicated that matrix metalloproteinases (MMPs) such as MMP-2 [44], MMP-7 [45] and MMP-9 [46] play important roles in the migration of ECs [47] and even angiogenesis of various cancers [48] by degrading extracellular matrix (ECM) and releasing various growth factors [49]. The gene discussed is MMP2; the disease is cancer.