With respect to the signaling pathway(s) responsible for the increased production of VEGF-A and IL-8 in the GATA6-overexpressing human CRC clones, we assessed the involvement of NF-κB pathway because this transcription factor has previously been shown to stimulate the production of a variety of proangiogenic factors including VEGF-A and IL-8 [67]. This evidence concerns the gene CXCL8 and colorectal carcinoma.