Together, our findings demonstrate that a stronger angiogenesis-stimulatory effect of the CM collected from the stemness-high GATA6-overexpressing human CRC cells is due mainly to the presence of higher amounts of two proangiogenic factors, VEGF-A and IL-8, whose production is stimulated by the EGFR/AKT/NF-κB pathway (Figure 6C). The gene discussed is CXCL8; the disease is colorectal carcinoma.