GATA6 and colorectal carcinoma: In this regard, the stable clones established previously by us from HCT-116 and HT-29 human CRC cells with enforced expression of GATA-6, a zing finger-containing transcription factor, exhibiting marked increases in the stemness properties such as the sphere- and soft agar colony-forming abilities as well as the expression levels of several CRCSC markers [43], were good stemness-high CRC models.