INS and obesity due to melanocortin 4 receptor deficiency: Among the obesity-related up-regulated miRNAs, several are involved in insulin and glucose homeostasis: miR-221/222 are shown to negatively regulate adiponectin receptor 1 (ADIPOR1), which promotes insulin sensitivity [98], and induces EMT in BC [99]; miR-520e and miR-141 specifically control glucose and lipid homeostasis [100]; miR-4454 regulates splicing variants of insulin receptors [97].