Because of the crucial role of OPG and RANKL in bone remodeling, the genes encoding for OPG (TNFRSF11B; gene map locus 8q24.12) and RANKL (TNFSF11; gene map locus 13q14) have been considered as promising candidates for osteoporosis [12,13]. Here, TNFRSF11B is linked to osteoporosis.