TNFRSF11B and osteoporosis: For SNP rs2073618 in OPG, a significant adjusted odds ratio of CG genotype (OR = 0.6, 95% CI = 0.3–0.97, p = 0.041) and the combination of GG + CG genotypes (OR = 0.6, 95% CI = 0.3–0.9, p = 0.029) in OPG rs2073618 indicated that individuals with these genotypes have a 40% lower risk of developing osteoporosis than individuals with the CC genotype.