Consistent with a role for CDK4/6 signalling in glycolysis, either depletion or inhibition of CDK4/6 enhances glucose, as well as glutamine and amino acid metabolism, in RAS-mutated HCT116 colorectal cancer cells [18] and increases glycolytic and oxidative metabolism in pancreatic ductal adenocarcinoma cells [19]. The gene discussed is CDK4; the disease is colorectal cancer.