PPARGC1A and melanoma: To investigate the palbociclib-driven changes in mitochondrial metabolism, we examined mRNA expression or protein levels of key regulators of mitochondrial biogenesis in melanoma (MITF, PGC1α and TFAM) [14,16] (Figure S2) as well as protein levels of key components of the five mitochondrial OXPHOS complexes (Figure 2e).