APOE and atherosclerosis: Recently, Centa and colleagues addressed a question on the overall role of immunoglobulins in atherosclerosis using hypercholesterolemic mice that have a defect in Ab production within an otherwise normal immune system using Prdm1fl/flCd19cre/+Apoe−/− and control Prdm1fl/+Cd19cre/+Apoe−/− mice [157].