The immunization of Ldlr−/− mice with Streptococcus pneumonia led to elevated levels of oxLDL-specific IgM and an expansion of oxLDL-specific splenic T15 IgM-producing B cells, which were cross-reactive with pneumococcal determinants, and subsequent weakened atherogenesis [120]. Here, CD40LG is linked to streptococcal pneumonia.