Using adoptive transfer of CD40-deficient B cells into μMT−/−Apoe−/− mice [161] or mixed Ldlr−/− chimera (80% μMT−/−, 20% Cd40−/− BM) [100], Tay and colleagues demonstrated that B cell-specific CD40 deficiency diminishes the development of atherosclerosis in the aortic sinus and in the innominate artery. The gene discussed is CD40; the disease is atherosclerosis.