Additionally, while the overlap of BLIMP-1 and XBP-1 functions is restricted to the unfolded protein response, BLIMP-1 serves at the upstream of XBP-1 and uniquely regulates mTOR activity and plasma cell size [156], and therefore might have additional effects on the B cell population in atherosclerosis. The gene discussed is XBP1; the disease is atherosclerosis.