LEP and type 2 diabetes mellitus: Compared to ZL-BMMSCs, ZDF-BMMSCs exhibited enhanced adipogenesis, a phenomenon also observed in db/db mice [42], in WNIN/GR-Ob (mutant) rats [43] and in a patient with T2DM [44], suggesting that the BMMSCs removed from a hyperglycemic and hyperinsulinemic T2DM-state retained the enhanced adipogenic potential.