FOXO1 and type 2 diabetes mellitus: Furthermore, growing evidence suggests that, in a T2DM context, the miRNA expression in MSCs is modified, as it has been shown recently that T2DM-adipose derived MSCs, showing reduced viability and proliferation, exhibit significant differences in the expression of miRNAs involved in cell proliferation (miR-16-5p, miR-146a-5p, and miR-145-5p), as well as miRNA and genes responsible for glucose homeostasis and insulin sensitivity (miR-24-3p, 140-3p, miR-17-5p, SIRT1, HIF-1α, LIN28, FOXO1, and TGFβ) [41].