According to literature data about the association between the presence of AI in specific microsatellite loci and the risk of HCC recurrence, we analyzed 17 loci located within or adjacent to specific genes of interest: 1p (L-myc), 1p (CMM), 3p (VHL and OGG1), 5p (MCC), 5q (APC), 9q (PTCH), 9p (CDKN2A/p16), 10q (PTEN), 17p (TP53) and 18q (SMAD4). This evidence concerns the gene APC and hepatocellular carcinoma.