Time-to-recurrence analysis showed that LOH in the PTEN loci (involved in the PI3K/AKT/mTOR signaling pathway) was significantly associated with a lower risk of HCC recurrence (HR: 0.35, 95% C.I.: 0.13–0.93, p = 0.036, Table 4). This evidence concerns the gene PIK3CA and hepatocellular carcinoma.