The proteome of ME/CFS patients’ cerebrospinal fluid has led to conclusions centered around axonal guidance pathways, also linked to the ephrin-Eph signaling pathway, along with an interest in the complement pathways, with C3 being one of them, which has a protein correlation network that is severely disrupted in our dataset (Table 6) [52]. This evidence concerns the gene C3 and myalgic encephalomeyelitis/chronic fatigue syndrome.