TP53 and carcinoma: Though p53 mutational pattern is now considered a reliable marker for a diagnosis of HGSC, two important caveats have to be considered: (1) 4% of HGSCs are p53 wild-type; (2) almost 20% of ovarian endometrioid grade 3 carcinomas (morphologically similar to HGSC) and a minor subset of CCC are p53abn [15,16].