This review highlights the protein-coding and non-coding genes from DLK1-DIO3 and IGF2-H19 imprinted loci, as well as individually imprinted genes DNMT1, PLAGL1, ZFAT, RB1, and WT1 as promising candidates for uncovering the role of POE in MS. This evidence concerns the gene DIO3 and myeloid sarcoma.