In the context of animal models, the expression of miR-127 and miR-136 from the DLK1-DIO3 locus was increased in rats predisposed to EAE compared to EAE-resistant rats [80], which completely coincides with the data obtained for MS [44]; increased expression of other miRNAs from this locus, such as miR-434, miR-541, and miR-369, was also detected in rats predisposed to EAE [80]. This evidence concerns the gene DIO3 and myeloid sarcoma.