For example, in glioblastoma, the chemokine (C-C motif) ligand 5 (CCL5) and its receptor C-C chemokine receptor type 5 (CCR5) are involved in autocrine and paracrine cross-talk between glioblastoma cells and the TME, contributing to stromal and immune cell tumor infiltration and glioblastoma cell invasion [38,39]. This evidence concerns the gene CCR5 and neoplasm.