CAR NK cells targeting the glioblastoma cell-specific antigens EGFR, EGFRvIII, and HER2 have been generated from NK cells derived from the following: the peripheral blood of healthy donors, umbilical cord blood, induced pluripotent stem cells, and the NK-92 cell line, which all display features of activated primary NK cells. Here, EGFR is linked to glioblastoma.