Given the role of obesity and WAT inflammation in impaired glucose metabolism, we next evaluated the effect of omega-3 PUFAs on glucose homeostasis; it was improved specifically in krill oil-supplemented mice (i.e., ω3PL and ω3PL-R), as evidenced by lower FBG and non-fasting plasma insulin (Table 1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.