Several studies have demonstrated the presence of autoantibodies in patients with ME/CFS against numerous cellular components including anchorage molecules [89,90], heat shock protein 60 [91], human nuclear dUTPase [48], microtubule associated protein 2 [92], muscarinic cholinergic and β-adrenergic receptors [93,94] nuclear envelop protein lamin B1 [95], serotonin [96,97] and single and double stranded DNA [98], resulting in the hypothesis that ME/CFS may represent an autoimmune disease [99,100]. The gene discussed is HSPD1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.