CD8A and neoplasm: Upon activation, the primary form of cytotoxicity mediated by CD8+ T cells is through degranulation and the exposure of the target cell to granzyme B. Following the elimination of tumor cells, the magnitude of antigen-specific CD8+ TEFF cells decreases along with an influx of key regulatory stimuli such as Tregs and TGF-β cytokines that mediate restoration of tissue homeostasis.