In the linear regression model, it was found that pre-LT PLR was significantly predicted by tumor grading and tumor number, while pre-LT NLR was predicted by MELD score, Child–Pugh score and tumor grading; both 1-year post-LT PLR and post-LT NLR were significantly predicted by microvascular invasion and pre-LT AFP serum levels. The gene discussed is AFP; the disease is neoplasm.