For instance, the PFAS-to-lipid associations are explained in animal studies by transactivation of peroxisome proliferator-activated receptor α (PPARα) contributing to a liver metabolic pathway which plays an important role in the regulation of cholesterol and triglyceride levels; or oxidative stress has been proposed to be a key player in the pathogenesis of hypertension [44,45,46,47]. The gene discussed is PPARA; the disease is hypertensive disorder.