In addition to its function as a competitively endogenous RNA (ceRNA), sponging miRNA in human cancers [19], Snhg15 was described to be localized and to act in the nucleus, e.g., by interacting with EZH2 that catalyzes repressive trimethylation at histone 3 (H3K27me3) [20]. Here, EZH2 is linked to cancer.