The use of BRD0705 to selectively inhibit GSK-3α (IC50 0.066 μM vs. 0.5 μM of α or β isoform respectively [46]), revealed that inhibition of GSK-3α corrects excessive protein synthesis and ameliorates the susceptibility to audiogenic seizures in Fragile X syndrome (FXS) mice [47]. The gene discussed is GSK3A; the disease is fragile X syndrome.