There is evidence that the fluctuations in blood glucose levels known as glycemic variability (GV) has correlation with the endothelial dysfunction T2D patients, characterized by increased expression of adhesion (ICAM-1, VCAM-1) and proinflammatory molecules (IL-8, NF-κB) [149,153,154]. This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.