PARP1 and cancer: Raineri et al. showed that A375 cells treated with PARP1-i, AZD2461 in combination with onconase, a ribonuclease enzyme with strong antitumor activity in a number of cancers, inhibited the PARP1-NF-κB pathway, which resulted in reduced cell colony formation, migration, and invasion as well as elevated induction of apoptosis [47,48].