Furthermore, PARP1 was engaged in the promotion of oncogenic fusion genes, e.g., transmembrane protease serine 2 (TMPRSS2) - erythroblast transformation-specific related gene (ERG) (TMPRSS2-ERG) in prostate cancer or Ewing’s sarcoma breakpoint region (EWS) - Friend leukemia integration 1 transcription factor (FLI1) (EWS-FLI1) and EWS-ERG in Ewing’s sarcoma [24,25]. The gene discussed is ERG; the disease is Familial prostate cancer.