Amiri et al., using an in vitro model based on the Hs294T melanoma cell line and cultures of normal melanocytes, showed that the enzymatic activity of PARP1 was increased in malignant cells when compared to normal melanocytes, which resulted in PARylation of various proteins (and of PARP1 itself) with secondary dissociation of NF-κB from PARP1, binding of NF-κB to the CXCL1 gene promoter, and an increase in its transcription, which may indicate a potential role of PARP1 in the regulation of the immune response [42,43]. This evidence concerns the gene PARP1 and melanoma.