ESR1 and breast cancer: The antitumor effect of curcumin is exerted through different molecular-signaling networks involved in proliferation, ER, HER2 pathways and the regulation of genes related to breast cancer metastasis like TGF-α, TGFβ1, SERPINE1, PGAP3, MAP3K1, MAPK1, vimentin, among others [68,69,70].