For LRFS, the univariate Cox proportional hazard analysis showed that the postoperative undetectable HBV-DNA (p = 0.027), ascites (p = 0.024), albumin (p < 0.001), Prothrombin time (p = 0.027), AST (p < 0.001), ALT (p = 0.029), microvascular invasion (p < 0.001), BCLC tumor stage B (p = 0.001), clustered distribution of HBsAg (p < 0.001), diffuse distribution of HBsAg (p = 0.018), positive tissue HBcAg (p = 0.002), and predominantly cytoplasmic HBcAg (p = 0.002) were significant predictors. The gene discussed is GPT; the disease is neoplasm.