For OS, the univariate Cox proportional hazard analysis showed that the postoperative undetectable HBV-DNA (p = 0.027), preoperative serum HBV-DNA (p < 0.001), albumin (p < 0.001), AST (p < 0.001), Child-Pugh functional class B (p = 0.032), tumor number (p = 0.038), microvascular invasion (p = 0.023), macrovascular invasion (p = 0.008), BCLC tumor stage B (p = 0.006), diffuse distribution of HBsAg (p = 0.016), tissue HBV-DNA (p = 0.021), and tissue cccDNA (p = 0.025) were significant predictors. Here, ALB is linked to neoplasm.