AFP and neoplasm: For EMFS, the univariate Cox proportional hazard analysis showed that the antiviral therapy after the operation (p = 0.023), postoperative undetectable HBV-DNA (p = 0.007), HBeAg (p = 0.001), AFP (p < 0.001), maximum tumor size (p = 0.011), tumor number (p = 0.011), microvascular invasion (p < 0.001), macrovascular invasion (p = 0.001), BCLC tumor stage B (p < 0.001), positive tissue HBcAg (p = 0.002), and tissue cccDNA amount (p = 0.005) were significant predictors.