TP53 and Hyperglycemia: However, as epigenetic enzymes can regulate cell signaling pathways (e.g., NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα) [57], it is very likely that signal transduction pathways and transcription factors abnormally activated by diabetic conditions or hyperglycemia can cooperate, in a still not fully elucidated way, with epigenetic factors to promote sustained expression of pathological genes [58].