We found: (1) a unique miRNA signature that differentiated ALDH+ CSCs from ALDH+ normal SCs; (2) expression of four miRNAs (miR-200c, miR-92a, miR-20a, miR-93) were upregulated in CRC CSCs compared to normal colonic SCs; (3) miR-92a was upregulated in ALDH+ HT29 CRC CSCs; (4) miR-92a targeted the 3′UTR of LRIG1; and (5) miR-92a modulated proliferation of HT29 CRC cells. This evidence concerns the gene LDHA and colorectal carcinoma.