An example is shown where miR-99a/100, let7, and miR125b converge to block the TGFβ pathway and upregulate Wnt signaling in the disruption of hematopoietic stem cell homeostasis in acute megakaryoblastic leukemia (AMKL) [60]. This evidence concerns the gene TGFB1 and acute megakaryoblastic leukemia.