For example, MMP-2 responsive peptide-hybrid liposomes (liposome-like particles that incorporate MMP-2 cleavable peptides) designed to encapsulate and release pirfenidone (to down-regulate ECM production) at the site of the pancreatic tumors were able to down-regulate ECM material production and increase penetration of small molecules in a model of PDAC [124]. The gene discussed is MMP2; the disease is pancreatic neoplasm.