Continuous long-term (4–6 week) ELF-MF (50 Hz, 0.5 mT) treatment induced some signs of stress: HPA-axis activation (elevated blood glucose level, elevated POMC (the precursor protein for ACTH) mRNA level, and enhanced depression-like behavior in a forced swimming test), although other markers of stress (elevated basal ACTH and corticosterone secretion, adrenal gland hypertrophy, thymus involution, loss of weight gain, and anxiety-like behavior in elevated plus maze) were not observed. The gene discussed is POMC; the disease is Anxiety.