Bringing this further, Di Costanzo et al. accurately characterized a cohort of 83 blood donors with the mutant GG genotype (group G), 100 patients with features of the Metabolic Syndrome but the wild type CC genotype (group M), and 74 blood donors with the wild type CC genotype (controls) in the patatin-like phospholipase domain-containing 3 gene (PNPLA3). Here, PNPLA3 is linked to metabolic syndrome.