TP63 and cancer: Oocyte death resulting in Premature Ovarian Insufficiency (POI) can be triggered, for example, by chemotherapy and irradiation [44,45,46,47,48,49] as used for the treatment of cancer patients or by mutations in p63 [50] that abrogate the function of the C-terminal Transactivation inhibitory domain (TID) [51] (see also Section 5 below).