ZIC1 and urinary bladder cancer: Furthermore, SST and ZIC1 had significantly higher methylation levels in the nephrostomy urine (Mann–Whitney U test: p = 0.027 and p = 0.005, respectively) of bladder cancer patients than in the natural voided urine of benign hematuria controls, while for GHSR the difference was not significant (Mann–Whitney U test: p = 0.079).