This study aimed to evaluate the levels of SIgA/IgA, SIgM/IgM, and IgG specific to SARS-CoV-2 S1 or S2 subunit and reactive to HCoV-OC43 and HCoV-229E S1 + S2 subunits in milk from seven women with positive COVID-19 PCR test and six unexposed women (Ctl1-2018 pre-pandemic) as well as between 20 mothers that had viral symptoms during COVID-19 pandemic (no PCR test) and 16 unexposed mothers (Ctl2-2018 pre-pandemic). The gene discussed is CD79A; the disease is COVID-19.