Further, the very same were significantly higher after 3 × 8 Gy compared to 2 × 8 Gy whereas no differences between both fractionations were found for the stimulatory ligands 4-1BBL, CD70, ICOS-L, and OX40L (Figure 9h–o), in sum indicating a more suppressive tumor cell phenotype at 3 × 8 Gy. Here, ICOSLG is linked to neoplasm.