Impaired liver function as indicated by hyperbilirubinemia (total bilirubin >1.2 mg/dL) and pronounced hypoalbuminemia (serum albumin <28 g/L) occurred in 17/64 (27%) and 31/58 (53%), respectively (Table 2 and Table S2.1 and Figure S1). The gene discussed is ALB; the disease is Hypoalbuminemia.