In a 2017 RCT, Salekzamani et al. proved that in patients with metabolic syndrome, a weekly dose of vitamin D of 50,000 IU for 16 weeks significantly increased the level of vitamin D from insufficient to sufficient and significantly reduced the levels of cytokine IL-6, vascular cell adhesion molecule 1 (VCAM-1), and E-selectin, which are known to be involved in the adhesion process of the endothelial cells [52]. This evidence concerns the gene VCAM1 and metabolic syndrome.