In particular, HDACi upregulated NKG2D-L, such as MICA/B and ULBP1, on multiple tumor cell lines, both from hematological and solid tumors and on patient-derived acute myeloid leukemia (AML) cells, leading to increased sensitivity to NK cell-mediated cytotoxicity [154,155,156,157]. The gene discussed is MICA; the disease is neoplasm.