Radiotherapy and genotoxic stress can also induce the release of other DAMPs such as adenosine triphosphate (ATP), which can be bound and processed into adenosine (ADO) by multiple cells in the tumor microenvironment (TME) (e.g., tumor cells, regulatory T cells (Treg), and CD8+ T cells) through their expression of CD39 and/or CD73. The gene discussed is ENTPD1; the disease is neoplasm.