ATR and non-small cell lung carcinoma: For example, it was reported that single and repeated in vitro exposure of non-small cell lung cancer (NSCLC) cell lines to cisplatin lead to the upregulation of MICA/B through the regulation of ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia, and Rad3-related (ATR) signaling pathways, as well as other NKG2D-L (ULBP1, ULBP2/5/6, ULBP3, and ULPB4), resulting in increased NK cell activity [132,133].