SMYD3 and breast cancer: Four HMTs (ASH1L, SETDB1, SMYD2 and SMYD3) showed mRNA amplification in BL breast cancer while the mRNA levels of eight HMTs (EZH1, SMYD3, EHMT1, SETD7, PRDM4, SETD3, SETD1B, and PRDM6) were significantly downregulated and twelve HMTs (EZH2, PRDM15, PRDM13, SMYD2, SMYD5, SUV39H1, SUV39H2, EHMT2/G9a, WHSC1, SETD8, SETDB and SETD6) were significantly up-regulated in BL compared to other subtypes [39].