In vitro studies have shown that the miR-200 family(miR-200a, miR-200b, and miR-200c) is downregulated in TNBC cells and demonstrated a tumor-suppressive action mediated mainly through downregulation of EMT by targeting ZEB1/2, SIP1 and BMI1 proteins, inhibiting PKC [51] and mediating TGFβsignaling [52]. This evidence concerns the gene ZEB1 and neoplasm.