In addition, miR-181a-5p suppresses proliferation and induces apoptosis of glomerular mesangial cells by suppressing KLF6 and BCL2 expression via reduction of WNT/β-catenin signaling in human diabetic nephropathy [49] and of glioma cell lines through suppression of the gene encoding for Cyclin B1 [50]. Here, BCL2 is linked to central nervous system cancer.