In the present study, we analyzed the levels of TNF-α, IL-1β, and IL-6 in the hippocampus to validate the roles of Tat-SH3GL2 on ischemia-induced inflammatory responses because TNF-α promotes the migration of neurotrophils, IL-1β, and IL-6, which show pro-inflammatory roles. The gene discussed is IL1B; the disease is ischemia.