One of the most abundant cell types within tumor microenvironment is represented by cancer-associated fibroblasts (CAF), namely the fibroblasts that, corrupted by cancer cells through the secretion of cytokines and growth factors (e.g., TGF-β, IL-6), acquire a myofibroblast-like phenotype resembling that of wound healing reactive stroma [2]. This evidence concerns the gene TGFB1 and cancer.