In colorectal cancer, CAFs have been reported to induce upregulation of the human urothelial carcinoma associated 1 (UCA1) lncRNA in tumor cells, with subsequent increase of mTOR signaling, suppression of p27 and miR-143, and enhanced Cyclin-D1 and KRAS expression. The gene discussed is CDKN1B; the disease is colorectal cancer.