CAF-mediated downregulation of miR-205 in prostate cancer cells, which resulted to be dependent of a HIF1α-regulated oxidative and proinflammatory cascade [34,56], may also have profound clinical implications for the development of therapy resistance, in light of the fact that the miRNA has been proven to mediate sensitivity of tumor cells both to chemo- and radiotherapy [57,58]. This evidence concerns the gene HIF1A and neoplasm.