The authors performed an integrated analysis of miRNA and gene expression in (i) CAFs obtained from tumor tissues of patients subjected to radical prostatectomy, (ii) normal fibroblasts obtained from adjacent non-neoplastic areas, and (iii) the latter activated in vitro with TGF-β or IL-6, two known mediators of fibroblast activation [2]. The gene discussed is IL6; the disease is neoplasm.