Interestingly, the two miRNAs accomplish this effect by inhibiting genes of the same family, namely CDKN1A and CDKN1B. CCAL (colorectal cancer-associated lncRNA), transferred from CAFs to colorectal cancer cells via exosomes, was shown to confer resistance to oxaliplatin through the direct interaction with mRNA stabilizing protein HuR (human antigen R) and the consequent increase of β-catenin [97]. This evidence concerns the gene PROS1 and colorectal cancer.