Notably, in a subset of 10 samples of untreated primary gastric PDGFRA-mutant GIST, half carrying a D842V mutation and half carrying mutations other than D842V, it was found that the D842V mutant exhibits a significant enrichment of immune- and interferon-related gene signatures and, conversely, a downregulation of several oncogenes, transcription factors, and nuclear receptors [36]. This evidence concerns the gene PDGFRA and gastrointestinal stromal tumor.