Moreover, differential gene expression analysis revealed that 20 of 93 (21.5%) immune-related genes were significantly differentially regulated between PDGFRA and KIT-mutant GIST, with a significant overexpression of CCR5, BTLA, CD96, CD48, TNFRSF9, TNFSF8, CCR4, CXCL11, CXCR4, KDR, IL6R, TNFRSF8, TNFSF14, TIGIT, TNFRSF17, HLA-DQA2, CXCL14, and CXCL12 in the PDGFRA mutant subgroup. The gene discussed is PDGFRA; the disease is gastrointestinal stromal tumor.