In all the tumor settings studied, the role of EphA2, which ranges from a tumor-suppressive to a pro-tumorigenic one, depends on a number of intrinsic and extrinsic factors, some of which have been recently determined: its subcellular localization, the levels of expression, the presence of the ligand and the crosstalk with other receptors, such as the Epidermal Growth Factor Receptor (EGFR). Here, EGFR is linked to neoplasm.