UGDH and colorectal carcinoma: Even more, it has been determined that the treatment of colorectal carcinoma HCT-8 cells with either UGDH-specific small interference RNA (siRNA) or HA synthesis inhibitor 4-methylumbelliferone (4-MU) effectively delays cell aggregation [2], and the authors proposed UGDH as a potential target for therapeutic intervention of colorectal cancers.