UGDH and neoplasm: This effect was also observed when tumor cells were treated with EPI after UGDH knockdown, compared to the effect produced by EPI (siUGDH + EPI vs. EPI *** p < 0.001) (Figure 7A,B).The inclusion of a specific control with a hyaluronidase enzyme during the assay (HYAL) allowed us to estimate which fraction of this pericellular matrix is composed of HA.