However, deletion of α-SMA-positive cells in a pancreatic cancer preclinical mouse model (Ptf1-Cre; lox-stop-lox-KrasG12D/+; Tgfbr2lox/lox) leads to invasive, undifferentiated tumors that are more hypoxic and reduces animal survival [11]. The gene discussed is ACTA1; the disease is familial pancreatic carcinoma.