In a doxycycline-inducible pancreatic cancer mouse model (Ptf1-Cre; TetO-KrasG12D/+; Rosa26rtTa-IRES-EGFP; lox-stop-lox-Trp53R172H/+), depletion of CD11b+ myeloid cells (Itgam-DTR) increased intratumoral CD8+ T cells [39,40]. This evidence concerns the gene CD8A and familial pancreatic carcinoma.