Conditional deletion of LIFR leads to reduced pancreatic tumor progression and prolonged survival in a pancreatic cancer mouse model (Pdx1-Cre; lox-stop-lox-KrasG12D/+; Trp53lox/lox; Lifrlox/lox; lox-stop-lox-Rosa26Luc/Luc). Here, PDX1 is linked to familial pancreatic carcinoma.