Different tumor types express variable numbers of the known 28 types of collagens, which depending on their interactions with membrane receptors such as integrins, glycoprotein VI, and receptor tyrosine kinases (e.g., discoidin domain receptors 1 and 2, DDR1/DDR2) induce signaling cascades that enhance tumor progression, metastasis formation, and chemoresistance (reviewed in [8]). The gene discussed is DDR2; the disease is neoplasm.