The rapid decrease in flow may involve the zinc-sensing receptor, ZnR/GPR39 [78,79], and associated signaling pathways [80] triggering changes in tight junction characteristics, reducing electrogenic ion transport responses to secretogogues [27,29,31,81] and the magnitude of compromised epithelial barrier functions caused by Salmonella infection [82] and seminal fluid [83]. Here, GPR39 is linked to Salmonella Infections.