Modest increases in PGC-1α mRNA expression have also been observed in hippocampal neurons after exercise [84], status epilepticus [85], or after completion of memory retrieval tasks [86] with PGC-1α increasing the expression of brain-derived neurotrophic factor via upregulation of Fndc5 (Irisin; [84]). Here, FNDC5 is linked to status epilepticus.