TFAM and Parkinson disease: Accordingly, deletion of Tfam in dopaminergic neurons of mice (the Mito-Park model) causes a depletion of mtDNA and age-related loss of dopaminergic neurons of the SNc [230], and mice expressing mutant forms of Twnk selectively in dopaminergic neurons exhibit an increase in mtDNA mutations and dopaminergic neuron degeneration with a Parkinson’s-like motor phenotype [231].