A number of genes involved in mitochondrial function and responsive to PGC-1α overexpression in human neuroblastoma cells [70] are reduced, including ATP5A1 [259,260], glutamic-oxaloacetic transaminase 1 (GOT1; [259]), IDH3A [260], and malate dehydrogenase 1 (MDH1; [260]). The gene discussed is PPARGC1A; the disease is neuroblastoma.