Ubiquitylome analysis of a landscape induced by prostate cancer–associated mutations of SPOP in immortalized prostate epithelial cells expressing endogenous SPOP revealed DEK and TRIM24 as substrates consistently upregulated by SPOP mutants and with decreases in ubiquitination and proteasomal degradation (Table 1) [38]. The gene discussed is TRIM24; the disease is Familial prostate cancer.