Among the SUMOylated proteins in prostate cancer are the driving proteins such as AR [134,263,265,266,267,268,269,270], PTEN [271], p53 [216,272], ATF3 [273], FOXA1 [274], FOXA2 [275], CSR1 [276], TBL1 and TBLR1 [277], WWOX [278], pontin [279] SLUG [280], and SNAIL1 [281]. This evidence concerns the gene SNAI1 and Familial prostate cancer.