Specifically, the actions of an IL6/STAT3 axis are recognized as a major regulator of prostate cancer progression while the STAT5a/b plays a role in cell viability and growth, DNA repair, epithelial-to-mesenchymal transition (EMT), metastatic dissemination in preclinical models, and resistance to enzalutamide [7]. Here, STAT3 is linked to Familial prostate cancer.