The main drivers of prostate cancer progression, such as AR [44,45,46,134,431,432], PTEN/PI3K/AKT/mTOR [438], STAT3 [439,440], NKX3.1 [441] are influenced by PTMs, which changes their activity, expression, stability, and localization. This evidence concerns the gene NKX3-1 and Familial prostate cancer.