In a recent work, Vatapalli et al. [138] have shown that upregulation of MYC-regulated E3 ubiquitin ligases HECTD4 and MYCBP2 promotes AR and MYC degradation that leads to repression of MYC in a negative feed forward manner and regulation of the tumorigenicity of AR-positive prostate cancer cells. The gene discussed is AR; the disease is Familial prostate cancer.