GSK3B and Insulin resistance: Furthermore, in a recent in silico analysis performed in order to identify potential pharmacological target of H. dulcis compounds (especially flavonoids) among the main pathways involved in diabetes mellitus, including insulin resistance, glucose level and chronic inflammation, it was suggested that H. dulcis flavonoids may exert their antidiabetic and anti-inflammatory activity through the modulation of AKT1 and glycogen synthase kinase 3 beta (GSK3β) [79].