SMAD2 and cancer: Regarding the importance of miR-214-3p in cancer progression and its great interactions numbers with TGF-β compartments, especially with SMAD2 and SMAD5 (55 interactions), this miRNA was predicted to be involved in the PPI network of TGF-β signaling pathway and ZEB2, and it was hypothesized that miR-214-3p/ZEB2/SMAD-dependent TGF-β axis has a vital role in glioblastoma induction or progression (Figure 3).